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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Renowned forensic scientist speaks at the UFS

2014-04-02

Forensic science is about the truth. At the presentation delivered by Dr David Klatzow, were, from the left: Tinus Viljoen, lecturer in Forensic Genetics, Dr Klatzow and Laura Heathfield, also a lecturer in Forensic Genetics.
Photo: Leonie Bolleurs

It is necessary for more research to be done in the field of forensic science in South Africa. This is according to Dr David Klatzow, well-known forensic scientist, during a lecture delivered at the University of the Free State (UFS) last week.

The university is offering, for the first time this year, a BSc degree in Forensic Science in the Department of Genetics. This three-year degree is, among others, directed at people working for the South African Police Service on crime scenes and on criminal cases in forensic laboratories. Students can also study up to PhD level, specialising in various forensic fields.

There is no accredited forensic laboratory in South Africa. “It is time to look differently at forensic science, and to deliver research papers on the subject. In light of the manner in which science is applied, we have to look differently at everything,” Dr Klatzow said.

Dr Klatzow praised the university for its chemistry-based course. “Chemistry is a strong basis for forensic science,” he said.

A paradigm shift in terms of forensic science is needed. Micro scratches on bullets, fingerprints, DNA, bite marks – all of these are forensic evidence that in the past led to people being wrongfully hanged. This evidence is not necessarily the alpha and omega of forensic science today. DNA, which seems to be the golden rule, can produce problems in itself. Because a person leaves DNA in his fingerprint, it is possible that DNA is transferred from one crime scene to another by forensic experts dusting for fingerprints. According to Dr Klatzow, this is only one of the problems that could be experienced with DNA evidence.

“No single set of forensic evidence is 100% effective or without problems. Rather approach the crime scene through a combination of evidence, by collecting fingerprints, DNA, etc. It is also very important to look at the context in which the events happened.

“A person sees what he expects to see. This causes huge problems in terms of forensic science. For example, if a criminal fits the profile of the perpetrator, it doesn’t follow that this specific criminal is the culprit. It isn’t what we don’t know that gives us trouble, it’s what we know that isn’t so,” Dr Klatzow said.

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