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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UFS academic discusses Dutch, Afrikaans and African languages
2006-05-22

During the colloquium presented in Belgium by the Province Antwerp were from the left Prof Pol Cuvelier (University of Antwerp), Prof Theo du Plessis (Director: Unit for Language Management at the UFS), Mr Ludo Helsen (Permanent Deputy: Province of Antwerp) and Mr Jean-Pierre Rondas (Flemish radio journalist).

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UFS academic discusses Dutch, Afrikaans and African languages at international conference

Prof Theo du Plessis, Director of the Unit for Language Management at the University of the Free State (UFS), was the main speaker at a colloquium titled “Routes:  Where to now? - Een traject van het Nederlands naar het Afrikaans en de Afrikatalen”, which was recently presented by the Province Antwerp in Belgium.

 The aim of the colloquium was to discuss the future cooperation in the field of language between the Province Antwerp and South Africa. 

 The Province Antwerp is already involved with projects in South Africa.  One of these projects is the Multilingual Information Development Programme (MIDP), a partnership project between the UFS and the Free State Province that is mainly funded by the Province Antwerp. 

 The project has been running since 1999 and was recently in the news with the presentation of a symposium on multilingualism and exclusion on the Main Campus of the UFS.  It is hoped that the Routes colloquium will indicate new stages on which can be added to the already successful cooperation in the area of language.

 Prof Du Plessis’s presentation titled “Nederlands, Afrikaans en die Afrikatale – kan samewerking slaag? Die geval MIDP in die Vrystaat”, investigated the successes that have been made with the MIDP.  He discussed two possible approaches to cooperation in the areas of language, that of a sentimentalistic  approach against an instrumentalistic approach. 

Cooperation in the first approach makes language the aim.  In the second approach language is used as a means to a greater aim.  According to Prof du Plessis the first approach is driven by a romantisised idea about the relation between the Flemish and Afrikaans speaking people, which may unfortunately polarise the position of Afrikaans in South Africa even further.

 He argues that, given the time that we are in, the second approach will deliver more constructive results as language can among others be used for to further  democracy in South Africa.   This can happen by cooperation in the institutionalising of multilingualism in our society.  The more languages are used in education, law and government administration, the more we can be assured a successful democracy.

 The Routes colloquium was facilitated by the well-known Flemish radio journalist, Jean-Pierre Rondas. About twenty South African and Flemish language specialists took part in the colloquium.  Dr Fritz Kok, outgoing chief executive officer of the ATKV took part in the opening ceremony and Dr Neville Alexander from the University of Cape Town and well-known activist for multilingualism in South Africa was also one of the main speakers.

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