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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Prof Johan Spies learns about much more than genetics in Argentina
2014-04-23


People who attended the course enjoyed Argentina and its traditions very much.

Prof Johan Spies from the Department of Genetics visited Argentina, where he and Dr Carlos Acuna (Universidad Nacional del Nordeste, Corrientes, Argentina) presented a course for doctoral students and staff of Cerzos-Conicet Bahia Blanca (something like the equivalent of South Africa’s NRF) and Universidad Nacional del Sur, Bahia Blanca. Prof Spies presented chromosomal evolution and its effect on fertility, while Dr Acuna took care of apomixis.

Bahia Blanca is a city with a population of almost the same as that of Bloemfontein. The city lies at the mouth of the Naposta River, which almost forms a delta where it flows into the sea. Bahia Blanca (white bay) derives its name from the salt deposits that lends a white colour to the beaches.

The people are very friendly and one soon learns to extend a long arm in greeting. Otherwise you are stuck with an ‘Ola’ while men and women alike will grab even a complete stranger to plant a kiss on your cheek. For people who places great value on personal space, this friendly gesture is not always as welcome!

Barbeque is a choice dish and is usually in the form of beef rib. “It was great (especially if you shut your eyes and ignore the scrumptious fat and future heart attacks)! With the rib they usually had blood sausage and very tasty pork sausage on the grid. Everywhere people are sipping, through a silver straw, their ‘mate’ (pronounce maty), a type of tea made from the leaves and stems of Yerba paraguariensis. It is generally drunk from a special calabash ‘cup’ through a silver straw, which also serves as sift to keep the leaves from your mouth. The calabash is usually passed from one person to another, with each person taking a sip from the brew!  It is even passed around in class!  Another thing in conflict with the upbringing I received from my mother (as is the cup at communion)!,” says Prof Spies.

“My short visit also taught me that the Argentinians are a proud nation that often faced adversity in the past. Nevertheless, they do not try to change their past. Street names even refer to dates from their past when, for example, they were attacked by England (in 1807). Only the almost 30 000 people who disappeared under the military regime, are rarely talked about!,” says Prof Spies.

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