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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UFS Prestige Scholar shares her vision on crystallography with worldwide audience
2014-04-24

 
Dr Alice Brink
Dr Alice Brink, a Prestige Scholar and lecturer in the Department of Chemistry at the University of the Free State, was selected by UNESCO to participate, together with some 15 other young scientists from all over the world, in a round-table discussion at the Opening Ceremony of the International Year of Crystallography.

During this event, that took place in Paris, France, Dr Brink could, on stage, share her vision as one of the next generation of scientists.

“The 15 crystallographers consisted of eight young, established scientists and seven ‘young-young’ scientists who are starting their careers. We participated in a group discussion in order for the crystallographic community to better understand the challenges faced by young scientists across the globe.

“It was a great privilege to be invited to be part of this talented and diverse discussion group and to hear the challenges that are faced by young scientists from different parts of the world. It is also comforting to hear that scientific difficulties that are found in South Africa are commonly experienced in both First and Third World countries,” said Dr Brink.

“Crystallography has directly influenced the development of numerous scientific fields such as chemistry, physics, mathematics, medicine, engineering and material sciences. More inter-departmental collaboration would benefit greatly from crystallography, as this multi-faceted science provides foundation principles for applied research,” she said.

The United Nations declared 2014 as the International Year of Crystallography, and it was officially opened at the UNESCO Headquarters in Paris by the Secretary-General of the UN, Ban Ki-moon.

The ceremony was video-streamed live to more than 500 destinations all over the world.

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