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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Breeding of unique game requires a balance between conservation and sustainable use
2014-05-20

 

Game bred for qualities such as unconventional hair colour or horn quality, may on the long term have unexpected consequences for biodiversity and game farming.

This is according to the inaugural lecture of Prof Paul Grobler from the Department of Genetics at the University of the Free State (UFS).

Prof Grobler feels that the consequences of selective breeding should be examined carefully, as there is currently much speculation on the subject without sound scientific information to back it.

“At the moment, colour variation invokes much interest among game farmers and breeders. Unusual colour variants are already available in different game species. These unusual animals usually fetch much higher prices at auctions compared to prices for the ‘normal’ individuals of the species.”

Examples of these unusual variants are springbuck being bred in white, black or copper colours, the black-backed or ‘saddleback’ impala, and the gold-coloured and royal wildebeest.

A black-backed impala was recently sold for R5,7 million.

“Based on genetic theory, good reason exists why these practices need to be monitored, but one should also take care not to make the assumption that selective breeding will inevitably lead to problems,” warns Prof Grobler.

Grobler says that negative characteristics in a species can sometimes unwittingly be expressed during the selection process for a unique colour. “It is seen, for example, in purebred dogs where the breeding of a new race sometimes brings underlying genetic deviations in the species to the front.” He also believes that some of these animals may not be able to adapt to changing environmental conditions.

“However, one should also look at the positive side: because of the good demand for game, including unusual variants, there is much more game in South Africa today than in many decades. Balance should be found between the aims of conservation and the sustainable utilisation of game.”

Research at the UFS’s Department of Genetics is now trying to establish the genetic effects of intensive game breeding and predict the impact on biodiversity.

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