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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Art on Disasters to heal communities
2014-05-27

 
Fadzai Nyamusamba showing interest in the work: "Working on fire". This artwork was painted and donated by Mariette Pretorius, a professional artist from Bloemfontein. This art piece will be displayed at the South African National Disaster Management Centre in Pretoria.
Photo: Supplied
The Disaster Management Training and Education Centre for Africa (DiMTEC) at our university, recently launched its Art on Disasters initiative at the Gallery on Leviseur in Bloemfontein. 

Disasters have a devastating effect on societies and are accompanied by fear, uncertainties and often post-traumatic stress disorders. The creative arts have the ability to comfort survivors and those affected by tragedy. Amid disaster, art serves as a memorial, aids in the healing process and helps these communities to interpret their emotions. 

This is precisely the main focus of the Art on Disasters project. It aims to develop paintings, sculptures, dramas, theatre productions, poetry and music in collaboration with artists. These productions will then be presented to communities at risk of, or affected by, disasters, to create awareness and foster healing. 

Furthermore, the initiative will conduct research on art as a form of therapy and co-ordinate rehabilitation experts to assist the relevant communities. The artworks collected by the project, will be sold or auctioned to help raise funds. The proceeds will then be donated to a worthy cause as part of DiMTEC’s commitment to community service. 

The project will help console and heal communities and aspire to generate greater resilience to trauma. It will also give humanitarian workers the opportunity to advocate for disaster risk reduction and offer them an opportunity for psychological debriefing after attending to affected communities. 

“We will collect different categories of art related to all forms of disasters. These include paintings, photography, sculptures, poetry, music, theatre productions and short stories,” said Dr Andries Jordaan, Director of DiMTEC. “Stephanie Peters, Thomas Hart Benton, Tania Kovats and Medhi Naimi are just a few of the many artists that paint on man-made and natural disasters. They are artists that believe in art therapy as a form of self-expression, well-being and recovery,” he added. 

For more information about this initiative, or to possibly contribute as an artist, please contact Olivia Kunguma from DiMTEC on +27(0)51 401 9699 or kungumao@ufs.ac.za .

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