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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

University of Vermont bestows honorary doctorate upon Prof Jansen
2014-05-30

 
Vice-Chancellor and Rector of the University of the Free State (UFS), Prof Jonathan Jansen, was presented with an honorary Doctor of Letters degree from the University of Vermont (UVM). This special event took place on 18 May 2014 at a graduation ceremony in Vermont, USA.

Prof Jansen was honoured for the outstanding work he has done through various initiatives in South Africa and abroad. The University of Vermont especially highlighted the Leadership for Change programme, which sent two cohorts of first- year students from the UFS to UVM. This resulted in long-lasting ties between the students and staff of both institutions. "I am delighted and humbled by the international recognition for the work of the UFS and my small role in it," Prof Jansen said.

Prof Jansen was one of seven recipients of an honorary degree. One of these recipients was Samantha Power, the US ambassador to the United Nations and a member of President Barack Obama’s cabinet.

The UVM honorary doctorate citation reads, “Jonathan David Jansen is a leading public intellectual in South Africa renowned for his passionate dedication to education, social justice and the process of reconciliation. As Vice Chancellor of the University of the Free State (UFS), his leadership and his pioneering work is creating unity in the diverse academic community and transforming the atmosphere on campus. As an international expert, a leader in higher education, a scholar and a teacher, Professor Jansen works to inspire and educate the next generation of global leaders.”

In 2010 Prof Jansen received an honorary doctorate in Education from the Cleveland State University, also in the USA.

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