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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Make the right choices and you will succeed, Prof Jansen advises learners
2014-05-30

“You can make a choice today that will end up with you being pregnant, having babies, being unemployed, sitting at home like some of our brothers and sisters, uncles and aunts. Or you can make a different decision – and that decision is about you working so hard that you earn entry into the University of the Free State, get your degree and become great, not only in South Africa, but in the world.”

This was the message from the UFS’s Vice-Chancellor and Rector, Prof Jonathan Jansen, who addressed prospective Kovsies during our Open Day on the Qwaqwa Campus on Saturday 24 May 2014. Prof Jansen advised all learners to always make the right decisions.

“The first right decision is to pass well. You must go for 60%, 70% and 80% passes. Set yourself a target and do not just strive to pass, but to pass well,” Prof Jansen told a packed Rolihlahla Mandela Multi-purpose Hall, with learners coming from as far as Ficksburg, Lindley and Koppies.

“The second thing that you need to do, is to believe in yourself. Do not believe people who tell you what you can or cannot do. Believe in what you can do,” said Prof Jansen.

“Thirdly, you have to get up and do things for yourself. You have to work hard, sleep less and study hard. Don't accept excuses. If you can do these three things, then the best place to study is the University of the Free State. Believe that the sky is the limit.”

“We learned a very valuable lesson here today,” said Tumelo Mofokeng from Nkarabeng Secondary School in Kestell.

The fun-filled programme included performances and messages of encouragement from current students who have been part of the unique Leadership for Change Programme. This programme equips first-year students with skills to reflect, dialogue and engage on issues of diversity and leadership.

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