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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Prof Combrink gives 32nd DF Malherbe Memorial Lecture
2014-06-04

Since 2006, Prof HJB Combrink is the project leader of ‘Die Bybel: ’n Direkte Vertaling’. Prof Combrink addressed an audience on the subject of the project at the 32nd DF Malherbe memorial lecture. During the memorial lecture, he quoted DF Malherbe in order to create the context between the recent Direct Translation and the 1933/53 translation which involved Malherbe.

“Some of the younger generation forget that they are standing on the shoulders of workers who served in the muddy ditches of vilification to procure the foundations of a cultural language, and speak belittling and with shrugged shoulders about the first attempts, or show a lack of good comprehension, while judging the verses and tales from the Patriotic period according to aesthetic norms.”

Prof Combrink said that the Direct Translation transpired in a different context than the 1933/53 and the 1983 translations. The direct translation was approached differently and is therefore more inclusive concerning the relevant processes and phases.

“The making of a direct translation was and undoubtedly remains a great challenge,” Prof Combrink said. “It is not always easy to find the correct Afrikaans expression for a Greek or Hebrew idiom or loaded term.”

“It is an ongoing exercise trying to sit in two chairs at the same time. (However), the Bible Society could frankly say that this direct translation is an honest and well-informed attempt to portray all of the communication clues from the Greek and Hebrew source texts in good Afrikaans.”

Prof Combrink was a minister of the Dutch Reformed Church in Wonderboom, Pretoria (1968–1970), lecturer at RAU, UP and SU (New Testament, 1970–2001), and Dean of the Faculty of Theology at the Stellenbosch University for two terms (1992-1994 and 1998–2000). 
 

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