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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Pres Steyn turns pink in anticipation of Vryfees

2014-06-06

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Australian artist Cigdem Aydemir vacuum packed the Pres Steyn monument on the Bloemfontein Campus’s Red Plain – in pink. Aydemir’s project, ‘Plastic Histories’, forms part of a public art project that encourages us to evaluate public monuments in their historical context.

By vacuum packing monuments, Aydemir alludes to their significance and preservation. At the same time, though, it reveals the nature of their contentious and gendered historical function. This is because most monuments in post-colonial countries typically celebrate men’s achievements in serving their nations.

In response, this project acknowledges the contribution of women from all races, communities and sexual orientations to the grand narrative of a post-apartheid South Africa.

Aydemir is also developing an app in collaboration with Australian artist Warren Armstrong. This will be used for augmented reality viewing of three city monuments – those of President Brand, General De Wet and General Hertzog. This means that visitors will be able to hold a smart phone or iPad in front of the monuments and view the monuments as if vacuum packed in pink plastic.

In conjunction with the public art project there will be an exhibition of digitally manipulated photographs of nineteen-century and contemporary male monuments in Bloemfontein. These photos will be exhibited at the Johannes Stegmann Gallery at the UFS Sasol Library from 15 July – 1 August 2014.

Public tours on the Bloemfontein Campus and into the city will take place on:

• Tuesday 15 July at 11:00,
• Wednesday 16 July at 14:00, and
• Saturday 19 July at 11:00.

Aydemir’s ‘Plastic Histories’ public art project is part of the UFS Programme for Innovation in Artform Development (PIAD) and the Vryfees arts festival’s partnership with the Australian-based SituateArt in Festivals initiative. This partnership is managed by the Salamanca Arts Centre in Tasmania.