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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

First Kovsie. First Free Stater. First Female. Prof Driekie Hay makes history.
2014-06-10

 
Prof Driekie Hay, Vice-Rector: Open and Lifelong Innovative Higher Education, was elected to the Board of the Afrikaanse Taal- en Kultuurvereniging (ATKV). It is the first time in the history of the ATKV that someone from our university – as well as from the Free State – has been elected to the Board.

To date, only a few women have been nominated.

“I see this election as recognition of the UFS’s vision to act as a national role player and make a difference through its Human Project and its pursuit of social justice and reconciliation,” says Prof Hay.

She was appointed in the cultural expert portfolio during the ATKV’s Annual General Meeting from 28 to 29 May 2014. In this position Prof Hay has to promote the Afrikaans language and culture on a national level – through an inclusive approach. Prof Hay’s goal is to build bridges between the different language and cultural groups. She would like to establish greater understanding between the various groups in our country. She feels it is important to give shape to “a new generation of South Africans that are no longer threatened by ‘otherness’, but will cherish the treasure of diversity.”

This appointment isn’t only a great honour, but also endorses Prof Hay’s expertise. “On a personal and professional level, this appointment means that they have confidence in my expertise, outlook on life and experience” she says.

Prof Hay will serve on the Board of the ATKV for a three-year term.

The ATKV is a cultural organisation with four main focus areas:

  • language,
  • the arts,
  • communities and
  • education.

 


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