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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Dreams come true
2014-06-11


Lizelke Klindt – part of the Kovsie family

 

“To be a Kovsie is awesome.” This is how Lizelke Klindt starts the conversation.

Who is Lizelke?

She is one of our top emerging academics. Expanding on her BSc in Astrophysics, she obtained an honours degree in Physics this year – cum laude – earning her the Dean’s and Senate Medal.

At this year’s Kovsie Open Day on the Bloemfontein Campus, Lizelke beamed across the stage at prospective students and their parents – embodying true Kovsie pride.  

Her academic journey has just begun, though. Lizelke is currently doing her MSc in Astrophysics. Her thesis focuses on the ‘Multi-wavelength Analysis of Unidentified Active Galactic Nuclei in the Fermi 2LAC Catalogue’.

“This will allow me to travel around to collect my own data and will broaden my skill set in order to reduce the various data,” she says.

Her achievements have gone hand in hand with hard work and grapping every opportunity the university has to offer, she admits. She also has a lot of praise for our university for offering research opportunities to graduates in their respective fields.  

“My studies have allowed me to travel a lot and to meet people from all over the world. I have made friends in Germany, Poland, Australia and other European countries.

“And the best part of it all is I get to fly a lot. I absolute love it. And if there was such a thing as a second life, I would definitely be a pilot or hopefully an astronaut. It’s a good feeling to be part of the Kovsie family.”

Lizelke plans to continue onto her PhD in the coming years. And then? She fervently wishes to get a post-doctoral position at the very same university that opened a world to her that she loves passionately. A world she has dreamt of since childhood.

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