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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Physical Planning lives in recaptured space
2014-06-18

When the Department of Physical Planning decided on a new office premises, the team decided to tackle the project with an overarching theme – recycling.

It is important for Physical Planning to not only dictate to other departments on campus, but to set the example themselves,” says Nico Janse van Rensburg, Director: Physical Planning at the UFS. 

Recaptured space

New office space on campus is simply not available. It was therefore decided to recover space and a store room was identified. “Fortunately, the storage area had ceilings. However, it was dilapidated and was sagging all over. To divert attention from the ceiling, we painted it in a dark colour and the walls white.

“All wiring was also done superficially. It draws the attention away from the uneven surfaces and simplifies work on the wiring. Instead of trying to hide it, we made a focal point of it,” says Janse van Rensburg.

Recycled building materials

Lots of the building material that was used to convert the storage space into offices, was recovered from other building projects on campus. Material that would normally be discarded was utilised creatively to not only serve a practical purpose, but also an aesthetic one.

A laboratory basin was used as wash basin. Remaining parts of granite slabs from other sites were utilised as top for the basin. Existing toilets were also reused. To enhance the atmosphere, new taps in an affordable, but durable range were installed.

Recycled furniture

We rambled through every possible store room to find furniture. Tables were simply sanded and varnished and look better than new. Even the cabinet at the entrance was saved from wind and weather and reused.

Hot and smart

Only one screen wall was built. It was left in raw brick, unplastered and unpainted to contribute to contrasting textures. Existing walls were left painted or unpainted as it was before.

“The environment that was created breaks down several existing perceptions. Such as the perception that everything has to match; everything has to be plastered and painted and many others. This is an example of how different materials can be combined to create a lively environment.

“Staff members have already moved into their new offices and are very satisfied,” says Janse van Rensburg. 

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