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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

KovsieSport Director named as top SA coach
2014-06-27

 

DB Prinsloo
Director of KovsieSport, DB Prinsloo, was named as South Africa’s Coach of the Year. He is currently coaching the renowned Johan Cronjé – the best SA men’s athlete for 2013, member of the SA Commonwealth team for 2014 and a former Kovsie. Last year Prinsloo was also the team coach for the South African team that competed in Moscow at the world championships.
Several of South Africa’s leading athletes are trained by Prinsloo. Apart from the loads of medals his athletes won at national championships, he trained quite a few athletes who donned the green and gold. Boy Soke and Dumisane Hlaselo are among them.

Furthermore, four of the ten leading athletes in the junior rankings of all times are current and former athletes of Prinsloo. He even trained top-class athletes such as René Kalmer and Annerie Ebersohn.

Since his high school years, Prinsloo had a great passion for athletics. He was himself an excellent athlete and used to be a former South African senior 3 000 m steeplechase champion.

Johan Cronjé’s performance on the track is a good example of Prinsloo’s talent as coach. Last year Cronjé was the only South African to win a medal at the World athletics championships in Russia, with his third place in the 1500 m. In addition, Cronje improved the South African record in the 1 500 m twice last year under Prinsloo’s guidance. Cronjé recently improved Johan Fourie’s 27-year-old South African mile record (1987: 3:50,82) to 3:50,70.

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