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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Reitz colleagues start their own company
2014-07-01

The University of the Free State (UFS) and the five colleagues implicated in the Reitz incident of 2008 reached the final chapter in the reparation process in restoring the dignity of these colleagues on Thursday 19 June 2014.

Mr Mothibedi Molete and Mss Mankoe Naomi Phororo, Emmah Koko, Nkgapeng Adams and Sebuasengwe Mittah Ntlatseng, former cleaning staff at the UFS, are now the directors of their own cleaning company, Mamello Trading.

Furthering on its promise to assist the new-found company, the UFS has also appointed Mamello Trading as a service provider responsible for services at its South Campus.

It has been six years since the Reitz incident at the UFS and Dr Choice Makhetha, Vice-Rector: External Relations, described the journey of the past six years as a learning experience for all the stakeholders.

“This journey continues as there is still work to be done, but every milestone achieved, deserves a celebration like today’s,” Dr Makhetha said.

In 2010 the UFS signed a deed of settlement with the colleagues which committed the UFS to help them establish a cleaning company. This was followed by a reconciliation ceremony in 2011.

In 2012 the UFS assisted with the registration of the company Mamello Trading.

Dr Makhetha explained that in 2013 the UFS assisted in training the new directors and mentoring them for 12 months. 

Earlier this year, Mamello Trading signed a cleaning contract of four years with the UFS. Three of the directors’ daughters also received bursaries and are currently studying at the UFS.

Advocate Mohamed Ameermia, Commissioner at the Human Rights Commission, congratulated the management of the UFS on the reparation and reconciliation process they followed in restoring the dignity of the five colleagues.

The directors of Mamello Trading each had a special message of their journey and thanks. Their messages were as follows:

Rebecca Adams – After the video was exposed, I was hurt and was psychologically affected. By offering their apologies to us, the four students indicated that what they had done was a mistake. As a parent, when a child apologises you must accept that apology.
Emma Koko – I was shocked after the video was shown in public. I had a mother-child-like relationship with one of the students and that video tarnished my image as a human being. During the time of reconciliation these students showed remorse for what they had done.
David Molete – I was devastated, hurt and fearful to meet people. I ended up at a psychiatric hospital and attended counseling services which helped me to heal. The students apologised and I accepted because they were sincere.
Mittah Ntlaseng – The video impacted negatively on my dignity. The UFS assisted us with visits to psychologists. Now I feel I am a business owner and it is an opportunity for me to rebuild my self-esteem. 

Naomi Phororo – Mamello Trading is a business venture which is going to bring changes to our lives and families. The training I have received has enabled me to know how to manage the business.

 

Issued by: Lacea Loader (Director: Communication and Brand Management)
Telephone: +27(0)51 401 2584
Fax: +27(0)51 444 6393
E-mail: news@ufs.ac.za

  

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