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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Powering the future
2014-07-10

 

Kovsie students with the organisers at the African Student Energy Summit.

Photo: Rirhandzu Marivate

Powering the future. This was the theme of the first-ever African Student Energy Summit. The event was recently hosted by the Cape Peninsula University of Technology (CPUT) in Cape Town. The summit was even more unique, since it was part of a global series of Energy Summits held simultaneously in the US, Mexico and Scotland.

Sixteen Kovsies, together with students from across South Africa, Nigeria, Ghana, Zimbabwe, DRC, Zambia and Cameroon united at this event. The main goal: to confront pressing energy challenges faced by our continent. During roundtable discussions, these students brainstormed issues such as the accessibility of energy, as well as driving efficiency and sustainability through the use of green energy.

Antoinette Nel, a Kovsie honours student in Spatial Planning, said, “Interacting with different speakers and students on green energy possibilities enhanced my understanding of how much can be done to change the current status quo on energy in Africa.”

During a student parliamentary session, the participants had to come up with recommendations on sustainable energy. These will be compiled in a document and sent to the African Union (AU).

“My biggest highlight was understanding the need for energy by most Africans, not for lighting or industrialised activities but rather for daily livelihood, for basic rights and services such as cooking, health and education,” said Justman Suh, also an honours student in Spatial Planning at Kovsies.

“We are creating spaces to challenge Afro-pessimism in Africa through these platforms,” Dr Elizabeth Rasekoala, Chairperson of Green Shift Africa, said during the summit. 



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