Latest News Archive

Please select Category, Year, and then Month to display items
Previous Archive
12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Media: Moshoeshoe-lesing waardevol
2006-05-29



Hoofartikel
29 Mei 2006

 

Waardevolle lesing

DIE eerste koning Moshoeshoe-gedenklesing van die Universiteit van die Vrystaat het sommer met die intrapslag prikkelende gedagtes opgelewer en wys dat dit ’n paslike en nuttige manier is om ook die bydraes van swart leiers in Afrika te eer.

Terselfdertyd verskaf die eerste gedenklesing wat deur prof. Njabulo Ndebele, vise-kanselier van die Universiteit van Kaapstad gelewer is, diep stof tot nadenke en debat.

Die gedenklesing kom juis terwyl al hoe meer wenkbroue gelig word oor die skepping van ’n ander forum, die Native Club, waarvan wit Afrikane uitgesluit word.

Dis die geesteskind van mnr. Titus Mafolo, politieke raadgewer van pres. Thabo Mbeki, en die doel daarvan is om ’n forum te verskaf vir Afrika-intelligentsia.

In teenstelling met die ras-eksklusiewe Native Club wat ’n ongelukkige teruggryp is na rasgegronde instellings onder die apartheidsbewind, het prof. Ndebele in die gees van die inklusiewe leierskap van koning Moshoeshoe van Lesotho die gedenklesing opgedra aan al dié mense in Suid-Afrika en elders wat die moed het om hul oorwoë mening uit te druk oor belangrike sake wat die samelewing in die gestig staar.

Hy het tereg bygevoeg dié lesing kom op ’n kritieke punt in Suid-Afrika se nuwe demokrasie.
Prof. Ndebele het daarop gewys dat koning Moshoeshoe – Lesotho het onder sy leierskap mense van verskeie dele van die subkontinent gelok – kon bewys dat verskeidenheid ’n bindende eienskap kan wees.
Jy bereik die grootste eenheid tussen onderskeidende entiteite waar jy relatief vrye ruimte aan hulle gee om hul eiesoortige kenmerke na vore te bring.

Prof. Ndebele het ook opgemerk ’n toenemende aantal hoogs intelligente, sensitiewe en toegewyde Suid-Afrikaners oor die klas-, ras- en kulturele spektrum heen, bely dat hulle soos nooit tevore nie, onseker en kwesbaar voel sedert 1994.

Hierdie koerant spreek ter aansluiting hierby die wens uit dat die ANC-regeringsalliansie sal toesien dat wie ook al die leiding vorentoe in dié alliansie oorneem, ook daardie saambindende eienskappe moet besit wat koning Moshoeshoe gehad het. En wat hy gebruik het om sy land uit te bou en te verenig.

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept