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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Music lecturer’s innovative app is a first in South Africa
2014-07-24

Dr Frelét de Villiers, lecturer at the Odeion School of Music (OSM) at the University of the Free State (UFS), is in the process of developing an innovative interactive mobile music application – Notes&Fun.

Notes&Fun is being designed to assist aspirant pianists. It will support beginners with notation and rhythmic patterns.

The app will display single notes, phrases or rhythmical patterns on the phone or tablet and then apply the built-in microphone to measure the frequency of the notes played on the piano itself. It will indicate whether you’ve played correctly, or if you have made a mistake, the correct note will be displayed. Notes&Fun consists of multiple levels, each with a practise and test mode that gradually increases in difficulty and complexity. As opposed to existing apps, Notes&Fun is conceptualised with immediate pitch detection and is applied with a real (acoustic) piano.

For the pilot phase of this initiative, the developing company Maxxor in Cape Town will create a demo app which can be downloaded for testing purposes and general feedback. Once the developing company and innovator are satisfied with the first phase, the product will be marketed vigorously on social media. The initial app will be free, but subsequent levels will need to be purchased. The developers will start a Facebook page where users of the app can add their latest scores and compete with other users. Initially the app will only be available on the Google Play Store due to the fact that more people own Android devices than Apple products. Once the product has proven to be financially viable, the developers will adapt it for the Mac App Store as well.

“The beauty of this app is that music has a universal language, so it can be marketed internationally and I am privileged to have the institutional support from the UFS Technology Unit regarding the judicial process and developing process of the product,” Dr De Villiers said.

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