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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Advocate Thuli Madonsela leads Law Symposium on corruption
2014-06-05

 

Advocate Thuli Madonsela speaking at the Law Symposium on corruption.

The Faculty of Law, Centre of Business Law held a symposium on corruption in the public sector. The symposium took place on 5 June 2014 in the CR Swart Auditorium on the Bloemfontein Campus.

In her keynote address, Public Protector Adv Thuli Madonsela highlighted the government’s efforts to curb the high rate of corruption prevalent in the South African public sector. She also pointed out the effect it has had on service delivery, especially in municipalities and key government departments.

This highly-anticipated event drew a large group consisting of members of the public, the judiciary, government, non-governmental organisations, as well as the business and academic sector.

Responding to questions from the floor, Adv Madonsela spoke of corruption as an on-going problem that should be tackled in a collective effort by government officials and the public alike. “Whistleblowers are our main hope in fighting corruption … The Protected Disclosures Act protects them … it is also management’s responsibility to protect whistleblowers,” she said.

The symposium featured several well-respected names, including:
• Prof Jonathan Jansen, Vice-Chancellor and Rector;
• Honourable Justice I van der Merwe, Judge of the Free State High Court and Chairman of the Council of the UFS;
• Honourable Justice FDJ Brand, Judge of the Supreme Court of Appeal; and
• Prof JJ Henning, Acting Dean of the Faculty of Law.

Other high-ranking legal professionals from the office of the Director of Public Prosecutions, PriceWaterhouseCoopers, the Free State High Court and the Institute of Security Studies attended the event.


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