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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

UFS welcomes two new deans in the faculties of Theology and Law

2014-08-04

The university council has approved the appointment of two deans: Prof Fanie Snyman, at the Faculty of Theology and Prof Caroline Nicholson, at the Faculty of Law.

Both professors offer the university a wealth of knowledge and experience in research and teaching.

Prof Fanie Snyman

Prof Snyman joined the university in 1984 as a senior lecturer in the Department Old Testament. His career followed a steadfast ascent which led him to attaining the title of professor and head of department the following year. On 1 July 2013, Prof Snyman took on the additional role of acting dean of the faculty.

As dean, he set out a clear vision of academic leadership with four primary focus areas: research, teaching and learning, internationalisation and regional engagement.

He is the author of eight books and contributed to seven internationally- and twelve nationally-published books. He has published nine articles in international journals and about 60 more in accredited journals.

Prof Snyman proposes to bring staff members together to extensively rethink and reposition the faculty in terms of identity, transformation and the way forward. “We live in a complex world, characterised by uncertainty and in constant change. This calls for complex but also innovative solutions,” he says.

Prof Caroline Nicholson

Prof Caroline Nicholson was born in Scotland and came to South Africa as a young child. She obtained her BProc and LLB degrees at the University of the Witwatersrand and completed her articles of clerkship at Chernin’s in Hyde Park Corner, Johannesburg. Prof Nicholson was admitted as both an attorney and notary public of the then Supreme Court of South Africa in 1986.

In 1986 she joined the University of South Africa (UNISA ) as a lecturer and remained there until 1999. During this time she completed an LLM in Banking Law and an LLD in Comparative Conflict of Laws – focusing on international parental child abduction. During the same year she moved to the Faculty of Law at the University of Pretoria where she worked for the last fifteen years. In 2003 she completed a Postgraduate Diploma in Alternative Dispute Resolution (ADR) and has an abiding interest in ADR, especially within the Family Law context.

Prof Nicholson has produced numerous articles and research presentations on a variety of legal subjects. Her primary areas of interest are, however, legal education and child law. She is known both nationally and internationally for her research contributions.

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