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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Transforming lives through reading
2014-08-11

 
The UFS Library and Information Services visited Lekhulong Senior Secondary School as one of their community development projects commemorating Mandela Day on 25 June 2014. Situated in the Bloemfontein township of Rocklands, the school’s library was depleted of books and in need of a total revamp. The group of change agents under the guidance and leadership of Marcus Maphile, Assistant Director: Information Services, consisted of seventeen library staff members, library ambassadors and volunteers from Student Life and Leadership.

A total of 450 books were donated to the school. The range of books was made up of mainly dictionaries and encyclopaedias. Fifty of these copies were acquired through the ‘Buy or Donate a Book’ campaign run by the library earlier this year.

In thanking the UFS library, the school’s principal, Mash Mawasha said reading has always been a challenge for his learners and that he is confident that this will be a major turning point for them.

The Director of Library Services, Betsy Eister, expressed the UFS library’s commitment to this project. She pledged regular visits to the school to ensure that Lekhulong library staff are trained on how to run the library and that teachers include library books in their teaching.

“We try to ensure that by the time learners arrive at universities,” Maphile said, “they have exposure to libraries, that they acquire a love for reading books and most importantly have confidence not only to express themselves but to use the library system efficiently.”

The book donation programme has been running successfully for two years and apart from revitalising school libraries in disadvantaged communities, the UFS library staff provides training and support to teacher librarians. Next year, the team plans to extend their project to another community in Bloemfontein – that of Headstart High School.


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