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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

A struggle without documentation is no struggle – exhibition by internationally acclaimed Dr Peter Magubane
2014-08-06

 
The latest exhibition of one of South Africa’s most internationally acclaimed photographers, Dr Peter Magubane, has arrived on our Bloemfontein Campus. The exhibition features photographs taken by Dr Peter Magubane from 1954 – 1994. From the township streets to the hallways of power, Dr Magubane has spent more than half a century photographing the struggle against apartheid and significant social issues.

The Johannes Stegmann Art Gallery, in association with Absa, are hosting the exhibition called ‘A struggle without documentation is no struggle’ from 13 August to 12 September 2014. The photographs are displayed in the Centenary as well as the Johannes Stegmann Galleries on the Bloemfontein Campus.

Dr Magubane has received numerous accolades for his dedication and outstanding contribution to the world of photography. These include:
• the Mother Jones-Leica Lifetime Achievement Award,
• the Martin Luther King Luthuli Award,
• a Fellowship from the Tom Hopkinson School of Journalism; and
• four Honorary Doctorates from various South African universities.

In the period from June 1969 to 1971, Dr Magubane spent a total of 586 days in solitary confinement and was later banned as a photographer in South Africa for five years. From the 1980s, he worked for Time magazine. In 1990 he was selected as Nelson Mandela’s official photographer to chronicle South Africa’s transition to a new political dispensation.

Today, Dr Magubane mainly focuses his lens on the diverse traditions and cultural practices of South Africans. 

Dr Magubane gave a presentation on 14 August 2014 in the Johannes Stegmann Art Gallery.

For more information, please contact Angela de Jesus at dejesusav@ufs.ac.za  or +27(0)51 401 2706.

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