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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Drawing Fire: Investigating the Accusations of Apartheid in Israel
2014-08-14

 Benjamin Pogrund
Photo: mg.co.za

Renowned journalist Benjamin Pogrund led a seminar on the current Israel/Palestine conflict in Gaza. The Department of Political Science hosted the event at the Bloemfontein Campus on 11 August 2014.

The discussion mainly centred around points Pogrund explores in his latest book, ‘Drawing Fire: Investigating the Accusations of Apartheid in Israel’.

Pogrund, who spent 26 years as a journalist in South Africa investigating apartheid, investigated the accusation that Israel is practicing apartheid and the motives of those who make it. His talk offered the audience a balanced view of Israel’s strengths and weaknesses and the problems facing the region. Pogrund drew a unique comparison between South Africa and Israel, explaining the complex political and social situations.

While researching and writing ‘Drawing Fire’, Pogrund experienced an intense emotional struggle. In the book, he explores the contradictions found in the region. It also deconstructs the criticisms against Israel as well as the boycott movement before arguing for two separate states – Israel and Palestine – as the only way forward for Jews and Arabs.

During the talk, Pogrund raised the question as to why the media coverage of Israel/Palestine conflict detracts so much attention away from the atrocities committed by ISIS currently terrorising the minority groups in Syria and Iraq.

Pogrund has been living in Israel for the past 15 years where he reports on the Israeli-Palestinian conflict. He was the deputy editor of the Rand Daily Mail – South Africa’s leading anti-apartheid newspaper during the 1980s. Among other publications, he has written for the Guardian (London), Haaretz (Tel Aviv) and Facta (Tokyo). In May 2013, he was awarded the prestigious Lifetime Achievement Award by the International Media Council in London, on behalf of the Next Century Foundation, for encouraging understanding of the Middle East and war-torn areas of the world.


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