Latest News Archive

Please select Category, Year, and then Month to display items
Previous Archive
12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Honouring Stanley Trapido – one of the most influential historians South Africa has produced
2014-08-14

 

Prof Charles van Onselen
Photo: Supplied

The International Studies Group and the History Department at the UFS hosted a seminar on Stanley Trapido by Prof Charles van Onselen on Monday 11 August 2014.

The seminar honoured the life and work of Trapido, one of the most important and influential historians South Africa has ever produced.

Trapido is probably best known for his work on the causes and consequences of the South African War of 1899–1902. It was to this broad time period that Prof Van Onselen spoke in his paper ‘The Political Economy of the South African Republic, 1881–1895’.

Prof Van Onselen’s lecture provided a major reinterpretation of the origins and causes of the Jameson Raid while emphasising that Paul Kruger’s ZAR was a state beset by crime and corruption. It was particularly fitting that Prof Van Onselen gave the inaugural seminar paper, since Trapido supervised his Oxford doctoral thesis.

The International Studies Group and the History Department were extremely honoured by Trapido’s widow, the Booker Prize nominated author Barbara, attending the seminar. They wish to thank her for donating her husband’s academic library to the UFS.

Following the Sharpeville massacre of 1960, the Trapido-couple emigrated to England. While there, Trapido began to shape what is now known as the ‘revisionist’ school of South African historiography. He argued the importance of analysing capital and class formation, which he maintained informed the racial ideologies that culminated in apartheid.

Prof Van Onselen’s inaugural seminar presentation will be followed later this term by papers from David Moore, Sabelo Ndlovu-Gatsheni and Giacomo Macola.

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept