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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Kovsies deliver eight Brightest Young Minds
2014-08-15


Front, from the left: Michael van Niekerk, Thabiso Letselebe and William Clayton; Back, from the left: Gopolang Kgaile, Thokozane Mahlanga and Mpho Sefo; Lisa Coetzee and Lehlohonolo Mofokeng were not present during the taking of the photograph.

Eight Kovsies have been selected as part of 100 delegates for the 2014 Brightest Young Minds (BYM) summit.

Thabiso Letselebe (Chief Delegate of the UFS BYM), Michael van Niekerk, William Clayton, Gopolang Kgaile, Thokozane Mahlanga, Mpho Sefo, Lisa Coetzee and Lehlohonolo Mofokeng will attend the BYM summit from 29 August to 2 September 2014 in Johannesburg.
BYM is a youth-driven non-profit organisation that identifies South Africa’s most passionate young people. The organisation equips these young leaders with the skills and networks needed to create positive change.

Each year, 100 participants are invited to a five-day summit, based on criteria of innovation, leadership, civic responsibility and academic accomplishment. Delegates discuss challenges facing the nation with respected leaders and then design start-up like solutions to these challenges.

Post-summit alumni have access to resources for success and BYM continues to encourage social entrepreneurship. BYM has demonstrated success in mobilising young people for nearly fifteen years.

BYM has been the launch pad for several successful business and social endeavours. Some of the ideas developed by BYM alumni include the AIDS Industry Management Standard, Taxi Smart Card System, MiniSass Water Monitoring System, Investec Young Women in Finance conference, Tertiary School in Business Administration, Twenty30 and Women in Engineering.

BYM attracts a diverse group of participants in terms of academic, racial, geographic and socio-economic backgrounds. In a society marred by divides, BYM is proving the power of diversity. The organisation’s participants would not be as successful in moving the nation forward if it were not for the diversity of their experience.

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