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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UFS researcher runner-up in 2014 Women in Science Awards
2014-08-18

 

Prof Jeanet Conradie
Photo: Supplied

Prof Jeanet Conradie, professor in the Department of Chemistry at the University of the Free State (UFS), was the runner up in the senior category for Distinguished Women Researchers: Physical and Engineering Science in the Department of Science and Technology’s 2014 Women in Science Awards. With this award, female scientists and researchers are encouraged and rewarded, and also profiled as role models for younger women. 
 
Science and research, by which new concepts are discovered, is her great passion. Due to this keen interest in science, Prof Conradie studied a variety of subjects during her undergraduate years, providing her with a vast knowledge and the necessary background for her current main research interest, which is a combination of various scientific fields. Her PhD in Chemistry, as well as her strong background in Physics, Computer Science, Mathematics and Applied Maths, influenced her choice of research interest and expertise to gradually develop in the direction of computational chemistry, which is a beautiful combination of chemistry and physics. 
 
Today, Prof Conradie’s research expertise is in computational chemistry, using the super computer and appropriate software to simulate, understand and predict the behaviour of atoms and molecules in real life. The use of computational chemistry makes it possible to study chemical reactions and phenomena that are impossible or too dangerous to study experimentally. Her research team also performs experimental work in the laboratory to combine and compare with the computational analysis. Based on the results obtained, new materials with specific properties are developed. 
 
“We are very proud of Prof Conradie. This award is the result of 14 years of hard word, a lot of it after hours. We are fortunate to have someone like you as colleague who puts guidance to students and learners first in research, teaching and community service,” said Prof André Roodt, Head of the Department of Chemistry at the UFS. 
 
Prof Corli Witthuhn, Vice-Rector: Research said: “Prof Conradie serves as a role model for younger academic scholars in higher education through her motivation, productivity and drive. She also serves as an example of how female scientist can reach the top of their profession while juggling both professional and family responsibilities. This is well deserved recognition for her outstanding research achievements”

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