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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Short course in Applied Conservation Genetics developed at UFS
2014-08-22

 

Photo: en.wikipedia.org

During discussions with stakeholders in Kenya in 2013, a need was identified for training in conservation genetics with an African emphasis. In answer, Prof Paul Grobler from the Department of Genetics developed a short course in Applied Conservation Genetics.

Some of the phenomena studied in this field include:
• hybridisation between species such as blue wildebeest and black wildebeest,
• wildlife poaching and
• potential inbreeding in small game-farm populations.

From the onset, the course has been developed as an international venture. To this end, Dr Frank Zachos from the Natural History Museum in Vienna, Austria, committed himself to the project. Dr Jamie Roberts from the Department of Fish and Wildlife Conservation at Virginia Tech University in the USA also came on board. Both pledged their time and expertise to the course – without any financial gain.

Subsequently, our Department of Genetics presented this short course at the National Zoological Gardens (NZG) in Pretoria earlier this year. The team of presenters included Prof Grobler, Dr Zachos and Dr Roberts. They were joined by Dr Desire Dalton from the Research Division of the NZG, who added valuable practical experience to the presentations.

The course assumes a degree of prior knowledge of population and molecular genetics. A strong emphasis is placed on practical applications. The programme includes a strong component of statistics and hands-on training in the many approaches and software used in population genetics.

The group that attended the course included a contingent from the Namibian Ministry of Environment and Tourism, Dutch postgraduate students currently working at the University of Johannesburg and delegates from across South Africa.

This successful meeting followed an experimental first round of the course presented in Nairobi during 2013, attended by representatives from Kenya, Malawi, Nigeria, Mexico and Belgium.


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