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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Inaugural lecture celebrates Qwaqwa founder, Morena Mopeli Mokhachane
2014-09-12

 

Photo: RooistoelTV

Every historical era presents its own challenges and creates its own leaders who take up the call to address those challenges.

This was expressed by Dr Nyefolo Malete who presented the Inaugural Memorial Lecture on 6 September 2014 at the Qwaqwa Campus. The lecture honoured the live of the Qwaqwa founder, Morena Paulus Mopeli Mokhachane.

Dr Malete said that Morena Mopeli played his part in history as a skilled negotiator, formidable team player and a liberator who held good human relations in high regard.

“Morena Mopeli lived at the time when Southern Africa was experiencing a moment of frustration and despair. It was faced with conflicts, battles, starvation and turmoil in preparation for a transformation that was to serve as the mirror of the political and social stage which existed until 1994,” Dr Malete said.

“He was a hopeful leader and thinker who played a critical role in assisting his brother Moshoeshoe to build and protect Lesotho where it was humanly possible. He participated in most of the negotiations with all the groups to create peace and protect the borders of Lesotho. He was a good, intelligent and formidable diplomat who was aware of his role as a leader. He was aware that he could influence the future through dialogue.”

Dr Malete said that Africa needs leaders like Mopeli. Leaders who can expand the capacity to remain open to possibilities and “envision a positive future in the face of uncertainty and to creatively construct pathways that can be embraced by all people who collectively seek to turn possibilities into reality.”

In attendance at the lecture were dignitaries from the Lesotho Royal House, the Free State Provincial Government and the Free State House of Traditional Leaders. 

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