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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Active citizenship key to building healthier communities
2014-09-22

Photo: Mamosa Makaya

The Office of Community Engagement in collaboration with Bloem Shelter, hosted a three-day Indaba on active citizenship. The focus of the event was to engage local government leaders, NGOs and social services groups on creating a society that is healthier, safer and more informed.

The over-arching theme of the Indaba centred on the strengthening of family structures, social and health service delivery, spiritual healing and counselling. Amongst the various speakers was Rev Jennifer Samdaan, Minister in the Methodist Church and community activist. During her presentation, ‘Youth, Women and Children at Risk in South Africa', she highlighted the challenges that women and youth in townships and rural areas deal with in their daily lives. One example is physical and sexual violence while commuting to school and work. Rev Samdaan’s organisation has been instrumental in engaging municipal authorities in the region of Kokstad to provide security and lighting on roads where women are most vulnerable to violent attacks as they commute from work.

Community workers discussed their contributions in the fields of marital and family counselling and mental health support services. They discussed the benefits of their collaboration with local judicial bodies and other community leaders to render services to victims of domestic violence.

Rev Billyboy Ramahlele, Director in the Office of Community Engagement, emphasised the role of leadership and the responsibility of political leaders and citizens alike to ensure accountability in the quest to build a healthier society.

Vanessa Booysen, a neonatal consultant for Newborn Care in South Africa, demonstrated the importance of bonding between mothers and their babies. She called attention to the negative effects on the development of babies when separated from their mothers and the future challenges this causes. Modern medicine also leads to fewer women giving birth naturally. Booysen stressed that "it matters how we are born". She encouraged health practitioners to go back to basics in maternal care to lessen the negative effects that pass onto children into adulthood.

The workshop concluded with an exhibition by various groups that showcased the information resources and services offered to communities in the Free State.

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