Latest News Archive

Please select Category, Year, and then Month to display items
Previous Archive
12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Emily Matabane transforms perceptions of the deaf community
2014-09-22

 

Emily Matabane

September is International Deaf Awareness Month and Emily Matabane – a lecturer at our Department of Sign Language – let us into the world of the deaf. A world she herself lives in.

Through the aid of Tshisikhawe Dzivhani, an interpreter, Matabane shared her experiences with us in a question and answer (Q & A) session.

Q: Tell us about your career as a lecturer in Sign Language.

A: I started working at the university as a Sign Language lecturer in 2000. I have a lot of deaf and hard of hearing people in my family and I also went to a deaf school. My mother is hard hearing and after graduation I taught her sign language. This made me want to teach other people sign language, who in turn will teach more people as well.

Q: What are common misconceptions about the deaf community?

A: Hearing people will often think you are stupid if you are deaf. But in fact we can still understand people – for instance, if they write down what they want to say when we don’t have an interpreter with us.

People also thought I couldn’t drive or buy a car because I am deaf – while I actually had a valid driver’s license. When I wanted to get a loan at the bank to buy my car, they wanted a doctor’s letter to prove that I’m allowed to drive, even though I have a license. Eventually, I did get the loan and I did buy the car!

Q: How can hearing people support the deaf community?

A: People can learn sign language. That is what I wanted to achieve when coming to university as a Sign Language lecturer. Hearing students who will become psychologists, teachers and social workers will be able to work with deaf people and perhaps teach others sign language too. Deaf people simply need more people to socialise with them.

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept