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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Work clouds and rhizomatic learning – Prof Johannes Cronjé teaches through technology in inaugural lecture
2014-09-29

Prof Johannes Cronjé 

Prof Johannes Cronjé has been appointed as visiting professor in the Faculty of Natural and Agricultural Sciences in collaboration with the Centre for Teaching and Learning. The driving force behind his appointment is to develop young and upcoming scholars in the field of online and blended learning at our university.The title of Prof Cronjé’s inaugural lecture, ‘Tablets, Painkillers or Snake Oil – a Remedy for Education?’ suggested a compelling event. Prof Cronjé did not disappoint.

“We live in a world where we carry more information in our pockets than in our entire head,” Prof Cronjé remarked. Interesting fact: an iPhone 4 has 16 million times more processing power than the Apollo 11 – the spacecraft that put the first man on the moon.

If students carry this much processing power in their hands, what should we be teaching students? Prof Cronjé asked. “I believe the answer to that is: we should be teaching them to teach themselves.”

Presenting his inaugural lecture in the same way as he would to his students, Prof Cronjé had the entire audience within minutes vigorously participating in the event.

Prof Cronjé advocates a process called rhizomatic learning. Knowledge, he explained, grows in a similar way to rhizomes’ roots – inseparably connected and seemingly without beginning or end. “Learning is a social aspect: people learn from one another.”

Making use of freely-available online applications, Prof Cronjé demonstrated the power of technology in the classroom. “My objective is to use technology to make people enthusiastic and motivated about the learning process.” Using their smartphones, tablets and laptops, the audience could effortlessly participate through connecting to each other by means of a virtual work cloud. “Knowledge is being created in the room as it happens,” Prof Cronjé explained, “motivating you to participate in this learning experience.”

“There are three things you need for group work to be successful: a mutual goal, individual responsibility and positive interdependence. Then it is real cooperative learning,” Prof Cronjé concluded.

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