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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Messages and mail – what people say about Kovsies
2014-10-02

 
Letters from Kovsie students, parents, the community and even visitors to our university from across the globe regularly pour into our mailboxes and onto our social media pages.

To give you a glimpse of what they say about our institution, here are a few examples:

•    If you continue with this innovative thinking then the UFS will soon become the Ivy League institution of South Africa. – Chris Abels, United Kingdom

•    My daughter loves Kovsies. She has really come out of her shell as a result of the wonderful environment created by Kovsie leaders. She is flourishing and has for the second year in a row achieved the distinction of being a top academic student. Once again, thank you for your kind assistance which clearly indicates to me that Kovsies treat their students like family and not merely a number. – Grant Combrink, Port Elizabeth

•    The state of the University of Free State inspired me to go back to school and do my law degree. The cleanliness and the mood of the institution was inspirational and not only to me but also to a few of my colleagues. – Joseph Peter Kgomo, a journalist with the public broadcaster

•    I arrived in Bloemfontein to begin a one year appointment as a Fulbright Scholar. I have remarked to friends and colleagues in America that we can learn a great deal about hospitality towards our foreign visitors by embodying the altruism demonstrated throughout your campus. Thank you for the opportunity to become a Kovsie. – Professor Brenda C Eppley, Professor at Area Community College in Harrisburg, Pennsylvania, USA

•    I would like to congratulate you on the job well done regarding transformation and integration thereof. Indeed, the UFS that I am in is not the UOVS that I was in. – Tefo Masoetsa

•    I attended the Oprah Winfrey graduation ceremony in 2009 and when Dr Desmond Tutu received his honorary Doctorate. On both occasions one felt something big and miraculous was happening and many in the audience were moved. You are doing something down there in the Free State that really deserves attention! – Joy Summers, Producer: Carte Blanche

•    There will be much more hurt before our country is healed, but it will be the Kovsie doctors, psychiatrists and teachers applying the plasters and it will be the Kovsie architects, quantity surveyors, jurists and farmers building and regulating a new country. – Marzanne Lombard, proud former member of Soetdoring and Welwitschia Residences

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