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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Zubeida Jaffer short film to feature on SABC3
2014-10-08

 

Zubeida Jaffer
Photos: Adrian Steirn, 21 Icons South Africa

The nation-building initiative known as 21 ICONS South Africa, was recently thrilled to announce that Zubeida Jaffer will feature in their second season due to her professional excellence as a journalist and author.

Jaffer is a well-known South African reporter and author and has been a writer-in-residence at the UFS for three years now. The 21 ICONS project was inspired by Nelson Mandela and has created a movement for positive change. By sharing the stories of iconic South African men and women, the intention is to inspire new generations to follow in their footsteps.

One icon is featured per week in a visual celebration of engaging and entertaining portraits and short films, along with an essay biography across multiple media platforms such as print, broadcast, outdoor and social media. Jaffer’s short film will be broadcasted on 2 November 2014 at 20:27 on SABC3 and her collectable portrait will be published in City Press on the same day.

Jaffer’s short film discusses her truth as a journalist and activist who was a key figure in the struggle movement in the Western Cape during apartheid. In an intimate conversation with Adrian Steirn (creator, photographer and director of 21 ICONS, Jaffer talks about her journey as a journalist who always seeks to uncover the truth and give people who don’t have a voice an outlet to express their views, opinions and thoughts.

Other iconic South Africans that have featured on 21 ICONS, were among others, Francois Pienaar (former Springbok rugby captain who won the 1995 Rugby World Cup), Pieter-Dirk Uys (satirist who used comedy and caricature to oppose the apartheid government) and Frene Ginwala (the first female speaker in the National Assembly of South Africa).

With the country celebrating 20 years of democracy, the message that everyone can do something to make a difference – which is portrayed in these powerful and inspiring stories that make up the second season of 21 ICONS – has been well-received by South Africans.

Be sure to get your City Press early and tune in on the evening of 2 November 2014 to see Jaffer’s feature on 21 ICONS.

Jaffer is also the publisher of the Journalist website (http://www.thejournalist.org.za/) launched earlier in 2014, of which the UFS is the founding member. The Journalist is “an independent, non-profit organisation working with the academic community and a range of credible online entities to make their knowledge more accessible to the wider public.”


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