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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Digital Storytelling empowers and liberates students

2014-10-17

In January 2014, Jode Brexa, an American Fulbright scholar, came to our university and moved into the guest room at Welwitschia residence.

It so happened that Brexa and Elize Rall, residence head of Welwitschia – better known as Wel-Wel – started talking about digital storytelling. Brexa’s Digital Storytelling project captured Rall’s imagination. Shortly thereafter, Brexa convinced the RC members of Wel-Wel to participate in the project.

Digital storytelling is, on the most basic level, the use of computer-based resources to tell stories. The idea is to combine the art of storytelling with multimedia – including graphics, photos, text, audio, image and/or music.

The Wel-Wel students were taught storytelling skills and each student’s unique story was recorded and edited. It was so successful that they then showed their stories to the Rector and Dean of Students. Brexa will now – with their permission – take their stories to America with her, where she will share it with her community.

During the weekend of 10–12 October 2014, the RC of Wel-Wel introduced 12 learners, who are currently in Grade 10 at the Christiaan Liphoko School, to the project. The learners stayed in the gazellie for the weekend and, in the course of a few days, learned how much power is locked up in their personal stories. They learned that everyone’s story has the power to inspire and empower.

Wel-Wel has been involved in various outreach projects to the community. However, this was the first time that Wel-Wel literally brought the community to their doorstep. This is also not a charitable project. It is uplifted students reaching out to the youth to empower them in order to empower others in turn.

Meanwhile, Brexa also linked the project to the university’s Schools Partnership Project. The programme works through mentorship programmes to uplift previously disadvantaged schools. Hands were also taken with Columba Leadership NGO – financed by Old Mutual.

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