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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

The mysterious origins and problematic significance of the Postamble
2014-10-20



Prof André du Toit (UCT) and Prof Pieter Duvenhage (UFS)
Emeritus professor from UCT’s Department of Political Studies, Prof André du Toit, delivered a presentation at the Bloemfontein Campus on 14, 15 and 16 October 2014 respectively. His presentations gave an in-depth exploration of the Postamble as founding text of the South African Truth and Reconciliation Commission (TRC).

This event was hosted by the Institute for Reconciliation and Social Justice, in collaboration with the Department of Philosophy.

Prof Du Toit’s papers were entitled:
•    A Need for Truth: Amnesty and the Origins and Consequences of the TRC Process.
•    Tracking down a belated and inconclusive amnesty pact: The obscure origins and problematic significance of the 'Postamble' as founding text of the TRC process (Part 1 and 2).

In his presentations he explored how the text of the Postamble came to be written. He also scrutinised the respective contributions of those who were involved in drafting the text. The significance of the Postamble – as it is understood in its historical context – was also a point of discussion.

Prof Du Toit raised some thought-provoking questions during the three days. What is the relation of the amnesty provision of the Postamble with the subsequent TRC amnesty process? How did a text without any particular reference to a truth commission come to function as founding text and discursive framework for the TRC?

He also investigated some of the main problems with the history and significance of the Postamble, as well as its mysterious origins. In addition, Prof Du Toit conducted a critical analysis of a set of newly-identified drafts of the text.

One of Prof Du Toit’s most substantive inquiries, though, was into the question: Was the amnesty provision of the Postamble the product of an underlying amnesty ‘pact’ between the NP government and the ANC?


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