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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Unconventional oil and gas extraction – study for Water Research Commission reveals possible impacts
2014-11-05

 

Photo: Legalplanet.org
The Centre for Environmental Management (CEM) at the University of the Free State (UFS) recently completed a three-year project for the Water Research Commission. The purpose was to develop an interactive vulnerability map and monitoring framework for unconventional oil and gas extraction (final report still to be published).

Due to the complexity of this field, a number of participants across different disciplines and universities were involved in this trans-disciplinary study. Contributors included the Departments of Sociology, Physics and Mathematical Statistics from the UFS, the University of Pretoria Natural Hazard Centre, Africa, as well as the Institute of Marine and Environmental Law from the University of Cape Town.

Unconventional oil and gas extraction, its related impacts and the management of this activity to ensure environmental protection, is a controversial issue in many countries worldwide. Since the extraction of oil and gas using unconventional techniques is an unprecedented activity in South Africa, the project focused on understanding this extraction process as well as hydraulic fracturing and identifying possible environmental and socio-economic impacts associated with this activity in the South African context. An understanding of the possible impacts could aid government during the development of policy aimed at protecting the environment.

The researchers subsequently identified indicators to develop an interactive vulnerability map for unconventional oil and gas in South Africa. The vulnerability map focuses on specific mapping themes, which include surface water, groundwater, vegetation, seismicity and socio-economics. In addition, the map provides information on the vulnerability of the specified mapping themes to unconventional gas extraction on a regional scale. This map is intended as a reconnaissance tool to inform decision-makers on areas where additional detail field work and assessments may be required. It can also be used during Environmental Impact Assessments and determining licensing conditions.

Lastly, a monitoring framework was developed, which describes monitoring requirements for specific entities – surface water, groundwater, vegetation, seismicity and socio-economics – for the different phases of unconventional oil and gas extraction. Such monitoring is an important part of environmental protection. It is especially important for South Africa to perform baseline monitoring before exploration starts to ensure that we will have reference conditions to identify what impact oil and gas extraction activities has on the biophysical and socio-economic environments.


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