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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Department of Chemistry receives accolades at international conferences
2014-11-11

 

From the left are: Prof Andreas Roodt, Renier Koen, Dr Marija Zbacnik and Prof Deon Visser.
Photo: Supplied

Staff members in the Department of Chemistry at the University of the Free State (UFS) excelled at recent international conferences. Prof Andreas Roodt, Head of the Department of Chemistry, was honoured at the Pan African Meeting of the International Year of Crystallography IYCr2014. This event was hosted on our Bloemfontein Campus and delegates from 22 countries delivered their papers at the congress.

Prof Roodt received a medal from the President of the Moroccan Crystallographic Association, Prof Abdelmalek Thalal, for 'Building Science in Africa through Crystallography as President of the European Crystallographic Association'. Prof Deon Visser gave a keynote lecture at this meeting, while Dr Marija Zbacnik, post-doctoral fellow in Chemistry, received a prize for the best poster presentation.

Similarly, Chemistry PhD student, Renier Koen, received the prize as best student speaker at the Light Metals AMI (Advanced Metal Initiative) conference held at Kwa Maritane in Pilanesberg. Plenary speakers included delegates from the United Kingdom, the United States, India, China and South Africa.

Profs Roodt and Visser received a special scroll for having produced the best student speakers at the AMI series of conferences for the past three years in a row. The previous best student lectures were presented by Maryke Steyn (2012) and Tinus Viljoen (2013).

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