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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

The UFS #FaceOfFacebook

2014-11-14

At the UFS, we are committed to our Human Project, which sets the standard for good behaviour and care. It reaches internally to our students and externally to our prospective students and our communities.

And so, the Kovsies #FaceOfFacebook was born from the need to communicate with students and thus become a virtual friend. Yearly auditions are held to choose the new face representing the UFS on Facebook. The successful candidate holds the title #FaceOfFacebook for the next 12 months, attending events and filming short video clips to post on our Facebook page.

We had a quick chat with our current #FaceOfFacebook, Katleho 'Blue' Letube …

Who is Blue?

"Media mistress, fashion phenom, diva divine darling, superwoman and lover of life.
I was born in a small town called Bothaville, where my mom and her side of the family are living . I started pre-school there, moved and completed my schooling career at St. Andrew's High School (a very proud S aint) in Welkom. That is where my dad and his side of the family are living . Also, I am a proud resident of House NJ vd Merwe and I am studying Governance and Political Transformation."

How do you balance everything you do?

"It's relatively easy for me to strike a balance between my academics, social life and leadership duties, because Jesus is at the centre of all that I do. He is my guide and my strength. However, I also take it upon myself to prioritise. Although I am a '' liker of things'' , I ensure that my academics are the priority and everything else falls into place perfectly."

Are you dating someone?

"Hahaha, wouldn't you just love to know? Well, yes I am off-market. I'm completely taken and I'm happy."

What drives you?

"I always feel the urge to expand myself by working harder, smarter, stronger, and more efficiently. If there's an extra mile to go, the strength inside me draws out the willingness and ability to go that extra mile."

What is it like being the #FaceOfFacebook?

"I have been privileged to be entrusted with this duty and I carry it out with pride and passion. Being the #FaceOfFacebook means you get to meet a new face on campus almost every day, because people recognis e you and want to know you better. This opportunity has opened many doors for me and has equipped me with skills that have allowed me to grow as an individual. Therefore I will forever be grateful."

Where are you going to be in five years from now?

"Five years from now I would like to see myself as a better person both personally and professionally, in a respectable and reputed position earned through my hard work and skills. However, do not be surprised if you see me as a presenter on Vuzu.TV."

Advice to prospective students?

"Do not be that pupil who enrolled at this awesome institute and never takes advantage of its kindness. The University of The Free State is an institution that offers an excessive amount of opportunities to students. Step up and get out of your comfort zone. See an opportunity, seek the opportunity and cease it. You are at a university that provides you with a platform for you to grow."

What's your favourite colour?

My favourite colours are Black, White and Blue – hahaha!!

Kovsies can keep in touch:

Facebook: Katlego Blue Letube
Twitter: @Princess_blue31
Instagram: katlegoletube

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