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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

A model of resilience – Dr Anja Botha probes into the ability to recover from trauma
2014-12-02

She may have been awarded her doctorate degree only in July 2014, but Psychology lecturer at the University of the Free State (UFS), Dr Anja Botha, is already making a name for herself with her latest research.

Her study aims to develop a model of resilience for South African adolescents exposed to trauma. “The broad field, within which I work, is that of Developmental Psychology, with a specific focus on child and adolescent development and therapy,” says Dr Botha. 

Resilience studies are situated within Developmental Psychology since normal developmental tasks – such as achieving self-confidence and building supportive relationships – contribute greatly to children’s resilience. Resilience broadly refers to the individual’s ability to ‘bounce back’ after being exposed to adversity.

“The model of resilience which I compiled was a good fit for my participant group, indicating that the model explains the development of resilience in these adolescents well. The factors that I found to promote resilience in the South African context include various coping skills, intra- and interpersonal strengths, family involvement, and school engagement.

“Thus, aside from my passion for resilience studies, I am also very much interested in coping, strength-based interventions, parental guidance and school-based programmes.”

Dr Botha was awarded a Donald J Cohen fellowship in August 2014 during the 21st World Congress of the International Association for Child and Adolescent Psychiatrists and Allied Professions. The fellowship is in recognition of her work as an emerging international scholar in the field of child and adolescent mental health. This award was based on both her research as well as her involvement in the training of postgraduate students in child psychology.

She is currently supervising a number of master’s students’ research on various constructs related to resilience.

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