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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UFS makes history as a second researcher – Prof Melanie Walker – receives NRF A-rating
2014-12-03

Prof Melanie Walker
Photo: Sonia Small

Prof Melanie Walker, Senior Research Professor at the University of the Free State’s (UFS) Centre for Research on Higher Education and Development (CRHED) has received an A1 rating from the National Research Foundation (NRF). This rating acknowledges Prof Walker as a leading international researcher – her work unequivocally recognised by peers world-wide for its high quality and wide impact.

This is the first time in our institution’s history that two A-ratings are awarded simultaneously. Prof Maxim Finkelstein from the Department of Mathematical Statistics also recently received an A2-rating in Probability and Statistics from the NRF.

“Achieving this outstanding rating,” Prof Walker says, “is not just an individual achievement. I have had tremendous personal support and rich intellectual collaborations from wonderful colleagues on the way. The award also recognises the Rector’s project to build a dynamic research culture at UFS.”

Prof Walker has been researching and writing about issues in education and higher education for over 20 years. In particular she is interested in opportunities into, through and beyond education across dimensions of dis/advantage, and how higher education contributes to building a decent society by removing inequalities in its own policies and processes.

Through her focus on capacity building – around the common theme of higher education, human development and social justice – Prof Walker is developing a dynamic cohort of new-generation scholars. Her research group of graduate students and post-doctoral fellows is drawn from countries not only in Africa, but as far afield as Finland, India and Vietnam.

Her networks attract international scholars to the UFS, who contribute to research projects, engage graduate students, and add a considerable contribution to research at our university.

In addition, Prof Walker fulfils a host of roles, which includes:

• Tier One National Research Foundation (NRF) Chair in Higher Education and Human Development.
• Vice-President of the international Human Development and Capability Association (HDCA).
• Fellow of the Academy of Science of South Africa (ASSAf).
• Honorary professor, University of Nottingham, UK.

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