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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Dr Abdon Atangana cements his research globally by solving fractional calculus problem
2014-12-03

 

Dr Abdon Atangana

To publish 29 papers in respected international journals – and all of that in one year – is no mean feat. Postdoctoral researcher Abdon Atangana at the Institute for Groundwater Studies at the University of the Free State (UFS) reached this mark by October 2014, shortly before his 29th birthday.

His latest paper, ‘Modelling the Advancement of the Impurities and the Melted Oxygen concentration within the Scope of Fractional Calculus’, has been accepted for publication by the International Journal of Non-Linear Mechanics.

In previously-published research he solved a problem in the field of fractional calculus by introducing a fractional derivative called ‘Beta-derivative’ and its anti-derivative called ‘Atangana-Beta integral’, thereby cementing his research in this field.

Dr Atangana, originally from Cameroon, received his PhD in Geohydrology at the UFS in 2013. His research interests include:
• the theory of fractional calculus;
• modelling real world problems with fractional order derivatives;
• applications of fractional calculus;
• analytical methods for partial differential equations;
• analytical methods for ordinary differential equations;
• numerical methods for partial and ordinary differential equations; and
• iterative methods and uncertainties modelling.

Dr Atangana says that, “Applied mathematics can be regarded as the bridge between theory and practice. The use of mathematical tools for solving real world problems is as old as creation itself. As written in the book Genesis ‘And God saw the light, that it was good; and divided the light from the darkness’, the word division appears here as the well-known method of separation of variables, this method is usually employed to solve a class of linear partial differential equations”.

“A mathematical model is a depiction of a system using mathematical concepts and language. The procedure of developing a mathematical model is termed mathematical modelling. Mathematical models are used not only in natural sciences, but also in social sciences such as economics, psychology, sociology and political sciences. These models help to explain systems and to study the effects of different components, and to make predictions about behaviours.”

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