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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Postgraduate Film and Visual Media Programme at UFS from 2015
2014-12-04

 

There is great excitement at the University of the Free State (UFS) about the approval of a new honours and master’s programme in Film and Visual Media to be offered at the Faculty of the Humanities as from January 2015.

Prof Suzanne Human, Head of the Department of Art History and Visual Culture Studies at Kovsies and Director of the new programme, says this will be an interdisciplinary Film and Visual Media programme. There will consequently be a strong theoretical-philosophical basis in the training, as well as the practical experiences of students. The UFS will be the only university in South Africa where this much emphasis is placed on the historical and theoretical aspects of film-making.

“The world of images is, in our day and age where we are overwhelmed by images on a daily basis, a central study field relevant across various disciplines and even links the natural and human sciences,” says Prof Human.

“Film, which replaced books in the lives of young people in many ways, is an exciting field of which most people have some knowledge and involves a broad field of information with wide relevance.”

The programme will be presented with the cooperation of international scholars and experienced experts from the local industry. Chris Vorster – better known as Ryno from 7de Laan – with more than 20 years of experience in writing, directing and performance for theatre and TV, was appointed as lecturer in Film-making Theory and Practice in the newly-built film studio as from 2 January 2015.

This new postgraduate programme is developed in cooperation with several UFS departments:
• Prof Suzanne Human and Johanet Kriel (History of Art and Visual Culture Studies);
• Prof Nico Luwes, Dr Pieter Venter and Debeer Cloete (Drama and Theatre Arts);
• Prof Helene Strauss (English);
• Dr Anthea van Jaarsveld and Dr Cilliers van den Berg (Afrikaans and Dutch, German and French).

Specific admission requirements apply. For example, students should have a related BA degree with a minimum achievement level of 65%. Admissions are limited and subject to selection, therefore students that are interested should apply as soon as possible.  

Admission requirements

For more information, please send an email to filmandvisualmedia@ufs.ac.za.

 

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