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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UFS Leads ASGISA Training
2006-07-17

The University of the Free State (UFS) has been appointed as training service provider for the national programme for the creation of small enterprises and jobs in the second economy. This major national programme has a target of creating one million jobs for poor people in rural and peri-urban areas, which forms part of the government’s Accelerated and Shared Growth Initiative (ASGI-SA). The main method of training will be through the formation of self-help groups and cooperatives with access to business support and micro finance.

Prof Frans Swanepoel, Director of the UFS Research Development Directorate, acts as advisor to the national programme leader, Ms Vuyo Mahlati.  Dr Aldo Stroebel, senior researcher at the UFS Research Development Directorate, has been appointed as programme co-ordinator, based at the UFS. Prof Basie Wessels, Director of the  Mangaung-University Community Partnership Programme (MUCPP), has been appointed as the training co-ordinator and Ms Sazini Ndlovu as programme assistant based at the Independent Development Trust (IDT) in Pretoria.

Dr Stroebel has co-ordinated the development of a training programme, while Prof Wessels presented the “training-of-trainers” course at the MUCPP last month. This course was attended by trainers and trainer-assistants, identified and selected by the local economic development groups in each of the nine provinces, as well as trainers from Hand-in-Hand (HiH), an Indian non-governmental organisation acting as counterpart to the UFS in the provision of training.

Pictured here at the training session at the MUCPP were from the left: Prof Frans Swanepoel, Mr Gnanavel Mookkan (HiH), Dr Rendani Ralinala (IDT), Ms Sazini Ndlovu (national programme assistant), Mr Chinnaiah Meenakshisundaram (HiH), Dr Aldo Stroebel, Ms Vuyo Mahlati (national programme leader) and Prof Basie Wessels.

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