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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UFS discontinues one Masters programme
2006-07-26

As from next year, the University of the Free State (UFS) will no longer offer one of its specialist master’s degrees in education – the M Ed in Education Management.

 The other six M Ed programmes that are currently being offered at the UFS will continue as normal.

 The decision to discontinue one of the M Ed programmes follows a national review of M Ed programmes in Educational Management and Leadership by the Higher Education Quality Committee (HEQC) of the Council on Higher Education (CHE).

 Of the 23 tertiary institutions whose M Ed programmes in Educational Management and Leadership were reviewed by the HEQC, only 7 received full accreditation.   

 “The findings of the HEQC affect only one of our M Ed degree programmes, namely the M Ed in Educational Management,” said Prof Magda Fourie, Vice-Rector: Academic Planning at the UFS

 “We will be paying full attention to the findings of the HEQC with a view to correcting some of the shortcomings that have been identified by the HEQC and will consider submitting a reviewed proposal for such a qualification in two years time,” she said.

 According to Prof Fourie, the programme currently has 30 students enrolled.  “These students – spread across their first and second years of the degree programme – will be allowed to complete their studies with the full support of the UFS and the School of Education,” said Prof Fourie.

 “The qualification that has been awarded to students who have already completed their studies for this specific M Ed in Education Management degree programme remains a valid qualification and is not affected by the HEQC review,” said Prof Fourie.

 She said the UFS welcomed the efforts of the HEQC to ensure that all academic programmes offered by higher education institutions meet certain standards.

“One of the primary problem areas in the M Ed in Educational Management offered by the UFS identified by the HEQC, was that the programme is too practice orientated and must be more theoretical to comply with the academic requirements of a master’s degree.  This was a result of the fact that the programme was initially compiled in consultation with principals and the provincial Department of Education to address their needs,” said Prof Fourie.

“The UFS will in the mean time offer an advanced certificate in Educational Management and Leadership from next year.  This is a new course that will stretch over a period of two years and will ensure that we can still address the needs of teachers and principals,” said Prof Fourie.

 “The UFS remains committed to providing top quality degree programmes in all its six faculties and will continue to work with the HEQC in ensuring that this actually happens,” said Prof Fourie.

Media release
Issued by: Lacea Loader
Media Representative
Tel:   (051) 401-2584
Cell:  083 645 2454
E-mail:  loaderl.stg@mail.uovs.ac.za 
25 July 2006

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