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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Tiny microbes may solve large problems of water contamination, says Prof Esta van Heerden
2014-12-08

Small solutions for big problems

According to Prof Esta van Heerden, professor in the Department of Microbial, Biochemical and Food Biotechnology at the University of the Free State (UFS), this might hold some truth in current terms of water treatment strategies for waste and industrial effluents.

“There is little doubt in popular literature that eminent water crises are looming, not only with respect to the supply, but quality and effectiveness of various treatment options as well. The UFS’s Department of Microbial, Biochemical and Food Biotechnology is partnering with the Technology Innovation Agency to evaluate water treatment technologies that are applied worldwide and to extend these new or adapted options to innovative and interested clients in South Africa,” says Prof Van Heerden.

“The research focuses on using extreme microbes to tackle big contaminations and the results are amazing,” says Prof Van Heerden.

These microbes are fast becoming the stars on sites and developing these exciting systems allows for greener treatment options. It is fascinating that they can deal with metals, including chromium and uranium, cyanide, petroleum and diesel.

Of utmost importance is the development of a treatment for acid mine drainage.

“Interests have been overwhelming and thus far partners have allowed pilot scale development on their sites with very promising results. These initiatives are driven by responsible partners who strive to be innovative and develop sustainable technologies for good quality water that can be released in the environment,” Prof Van Heerden says.

The research group has set up a pipeline to serve the water communities’ needs. It provides an accessible toolkit for water analysis. A tailor-made treatment option is also developed and showcased in the laboratories. It has the added benefit that Geosyntec Consultants, USA, will ensure faster roll-out by sharing their vast experience on any related aspects.

 

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