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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

The first female heart surgeon in South Africa is a Kovsie
2014-12-15


Dr Susan Vosloo is South Africa’s first female heart surgeon. She graduated from the University of the Free State (UFS) in 1980.

“Being a Kovsie student brings back great memories. I received great medical training at the UFS and have fond memories of my time at the university,” she says.

Dr Vosloo completed her internship in Pretoria and spent the following year in Critical Care Medicine at Universitas Hospital, Bloemfontein, before starting her surgical training in Johannesburg.

She is currently in independent private practice at the Netcare Christiaan Barnard Memorial Hospital in Cape Town, having also worked from 1998 – 2012 at the Vincent Pallotti Hospital in the same city.

Dr Vosloo maintains close ties with our university and has quite a number of additional roles to that of surgeon:

• member of the Council of the UFS;
• UFS Council Representative in the Senate;
• member of the Standing Advisory Committee of the School of Medicine, UFS;
• Kovsie Alumnus of the Year (1989);
• member of the Provincial Department of Health;
• Africa representative for the Paediatric Cardiac Intensive Care Society; and
• founding member of the World Society for Paediatric and Congenital Heart Surgery.

“I have always been proud of the medical training I received at Kovsies. I have worked and visited many institutions across the world and never felt less qualified. In fact, all the places I have worked and went to had high regard for the training I received and also accepted me in that way.

“I think the Department of Cardiothoracic Surgery at the UFS does some ground-breaking research that the university can truly be proud of,” Dr Vosloo says.

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