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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

A call for next generation of professors: Apply for the Vice-Chancellor’s Prestige Scholars’ Programme
2014-12-19

 

Examples of the rector's prestige scholars' international footprint: Dr Olihile Sebolai, Fulbright scholar (left) returned to the UFS after six months at the University of Birmingham and three at the University of Missouri. Dr Cilliers van den Berg (right) visited Cornell University on a ten-month sabbatical.

The Vice-Chancellor’s Prestige Scholars’ Programme (PSP) seeks to identify, develop and promote the next cohort of the most promising and talented UFS academic members of staff who obtained a doctoral degree within the last five years or will graduate by June 2015.

Scholars identified benefit from an intensive programme of academic and professional support that includes an advanced residential programme, exposure to leading scholars, concentrated reading and writing programmes, high-level seminar participation and presentation, nuanced publication schedules and personal mentoring and advice, including participation in the annual PSP mock NRF rating and the development of a postdoctoral intellectual project for funding submission (Thuthuka, and similar).

Past prestige scholars have become Fulbright scholars, received funding from among others the Association of Commonwealth Universities, the Japan Society for the Promotion of Science, Erasmus Mundus, NRF Blue Skies, Thuthuka, etc. They have spent time at universities in Canada, the USA, United Kingdom, Europe and Japan.

This year the selection process will be anticipated by pre-selection. Final selection to the programme will take place in September 2015. The selection is highly competitive, and aimed at those young scholars with the potential to obtain upper-level NRF ratings (Y1 and P).

Criteria for selection:

Recently obtained a PhD degree. 
Evidence of an active publication record. 
Early recognition of scholarly work, e.g. successful funding/grant applications and academic awards. 
The early development of a post-doctoral intellectual project that shows evidence of scholarly “potential” (defined by the NRF Y-category). 
Indication of the young scholar’s understanding of what their envisaged postdoctoral endeavours will contribute to the body of disciplinary knowledge. 
Full participation in the pre-selection residential programme and activities is a requirement for selection.

Call for interest: 2015 (PDF)

Requests for further information can be directed to Prof Jackie du Toit at dutoitjs@ufs.ac.za.

Applications close on 16 February 2015.

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