Latest News Archive

Please select Category, Year, and then Month to display items
Previous Archive
12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Kovsies welcomes first-years into the fold
2015-01-20

Three first-year students from the Kestell residence that attended the first-year welcoming.
Photos: Johan Roux


 

Few life experiences are as exciting as becoming part of a university. On Friday 16 January 2015, Kovsies embraced our first-year students into our family after great anticipation.

That evening, first-years and their parents streamed to the Red Square on our Bloemfontein Campus where they were formally welcomed. This event also served to kick off the 2015 Gateway Programme – an orientation programme for all our first-years.

Dr Choice Makhetha, Vice-Rector: External Relations, addressed the first-years and congratulated them on their excellent matric results.

“The fact that you are here is a testimony to the level you are able to work at,” Dr Makhetha said.“You will have fun and make friends at the UFS. Your friends will be from different backgrounds and speak different languages than you. Embrace it all. You are now a part of the UFS family.

President of the Student Representative Council (SRC), Mosa Leteane, also reassured first-years that they are where they belong – at a university that inspires excellence.“This is the only space where the university’s international relations give opportunity to first-years to travel abroad with our F1 Leadership for Change Programme,” Leteane said. “It is the only space where the rector openly talks to his students, without having an appointment. It is the only space in our country where no student goes hungry due to our No Student Hungry (NSH) Programme.”

The following evening provided a spectacular live show with well-known artists Karen Zoid and Vusi Mahlasela entertaining the crowd. They performed alongside the Free State Symphony Orchestra (FSSO) that added even more dazzle to this Gateway/NSH first-years concert.

On Saturday 17 January, the new-comers had an opportunity to visit their respective faculties and get to know the staff and facilities a bit better.

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept