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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

MSc student plans to FEED our hungry planet
2015-01-27

Photo: Hannes Pieterse

Since attending the 2014 Youth Ag-Summit in Canada, Lisa Coetzee – an MSc student in Plant Pathology in the Department of Plant Sciences at our university – developed a plan to address hunger:

FEED – Forum of Education, Empowerment and Development.

Coetzee, together with a junior lecturer at Plant Sciences, Marguerite Westcott, started this student association to tackle the issue of food insecurity head-on.

Education, empowerment and development “are keywords vital to the solutions to poverty. Hunger is an issue which is found in our own homes. One in every four South Africans is food insecure. Hunger kills more people every year than Aids, malaria and TB combined,” says Coetzee.

“This forum allows awareness to be raised about the hunger situation locally and globally. FEED is talking about hunger and it is assisting in reducing it by reaching out to communities which are in need.

“FEED is the generation which is going to make a difference in eradicating hunger,” Coetzee continues. “We want students to think about how they can feed the hungry through what they are studying”. For Coetzee it is a high priority to ensure that the youth are aware of the importance to feed our hungry planet in a sustainable way.

Her philosophy on relieving hunger and increasing food safety is to enhance the efficiency of crop production, ensure crop security and reduce mycotoxins in the food we eat.

During the 2014 summit, Coetzee was elected to represent the African delegates on the Youth Ag Summit Committee. Ever since, she has been enthusiastically active in the agricultural community. As 43% of the globe’s farmers are women, Coetzee also feels she acts as a voice for female farmers in South Africa.

An important lesson Coetzee has learned is that there is power in one person to make a change – that we should start small but think big.

If you would like to get involved in this project, contact Lisa Coetzee on +27(0)51 401 9681 or email coetzeela@ufs.ac.za.

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