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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

A tale of many cities – new dictionary of place names reveals our heritage
2015-01-28

 

‘The Dictionary of Southern African Place Names’ provides not only the answers, but also gives insight into how our places and our people were shaped. Penned by three academics from the University of the Free State (UFS), it is the fourth edition of this fascinating book.

Prof Peter Raper from the UFS Unit for Language Facilitation and Empowerment, together with his colleagues Prof Theodorus du Plessis and Dr Lucie Möller, created more than a reference book. They provide the reader with deeper understanding of events, our heroes, beliefs, values, fears and aspirations.

Jonathan Ball Publishers describes the book as “the most comprehensive glossary of Southern African towns, villages, railway stations, mountains, rivers and beaches. The 9 000 short entries incorporate data from sources dating as far back as 1486, encapsulating the linguistic and cultural heritage of all the peoples of the subcontinent, past and present.”

And what would the origin of the name Bloemfontein be?

This dictionary provides the following answer.

“Capital city of the Free State and judicial capital of South Africa. It was established in 1846 by Major HD Warden at a fountain on the farm Bloemfontein, originally owned by a Griqua, Mauritz Pretorius. It has been claimed to have been named after a person with the surname Bloem, or in honour of the Khoikhoi chief Jan Bloem, or after an ox with this name. Probably, however, it was named after flowers growing at the fountain, from Dutch bloem, ‘flower’, fonteijn, ‘spring’. The name is thought to be a translation from a Bushman name of which Mangaung is the Sotho adaptation; ma- is the Sotho plural prefix or class marker; the component ngau is comparable to the Bushman word //au, ‘flower’, and the final ng is cognate with the locative demonstrative ?, ‘that (one) there’. Bloemfontein attained municipal status in 1880.”




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